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Monday 31 December 2012

Cancer Screening Rates Have Fallen In US

Despite evidence that earlier diagnosis and improved treatment increases survival, rates of people seeking preventive cancer screening have fallen in the US in the last ten years. Failure of leading bodies to agree screening guidelines, plus reductions in workers with insurance cover could be among reasons for the decline, suggest researchers from the University of Miami Miller School of Medicine.
They write about their NIH-funded study in a paper published 27 December in the online open-access journal Frontiers in Cancer Epidemiology.

In the US, although numbers of cancer survivors have gone up as a result of improved diagnosis and treatment, cancer is still one of the most prominent chronic diseases that in 2011 killed more than 570,000 people.

Alongside a fall in rates of advanced cancer diagnoses in the US in the last ten years, has been an increase in the number of cancer survivors returning to work. The researchers suggest, in their background information, that keeping to a cancer screening schedule could be an important factor (as this helps detect secondary tumors early and reduce potentially limiting side effects).

However, their analysis reveals that although cancer survivors tend to show much higher rates of screening adherence, their numbers too have started falling off in the last three years.

Lead author Tainya Clarke, a research associate in the School's Department of Epidemiology and Public Health, says in a statement:

"There is a great need for increased cancer prevention efforts in the US, especially for screening as it is considered one of the most important preventive behaviors and helps decrease the burden of this disease on society in terms of quality of life, the number of lives lost and insurance costs."

"But despite this, our research has shown that adherence rates for cancer screenings have generally declined with severe implications for the health outlook of our society," she adds.

In January 2012, a new report by the Centers for Disease Control and Prevention (CDC) and the National Cancer Institute (NCI) showed that the percentage of people screened for cancer in the US remains below national targets for 2020, with rates lower among Asian and Hispanic Americans than other groups.

The NIH Study Also Looks at Workforce

For this latest study, Clarke and colleagues examined cancer screening adherence rates of the general public and cancer survivors and compared them to government-recommended "Healthy People" screening goals.

They looked at screening rates for colorectal, prostate, breast and cervical cancers. Not only did they compare rates between the general population and cancer survivors, but they also looked at rates among workers.

The data on screening rates came from National Health Interview Surveys conducted between 1997 and 2010 that in total covered nearly 174,400 people aged 18 and over. These annual surveys randomly sample the US population by household, and collect demographic and health information, including cancer history and cancer-related health behaviors such as cancer screening.

The Results

When they analyzed the data, Clarke and colleagues found that the general population did not meet the government's "Healthy People" screening goals for any type of cancer, apart from colorectal cancer (for this cancer, 54% of the general population underwent screening: the government's 2010 goal is 50%).

But among cancer survivors, who have a higher risk for cancer, the pattern was quite different. Their screening rates, for all types of cancer except cervical (this fell to 78% over the last ten years), exceeded the government goals.

However, the researchers also noticed a decline in the number of cancer survivors who went for cancer screening in the last three years.

Disparities Among Workers

The NIH Survey results also enabled the researchers to include data on working adult Americans with and without a history of cancer: including more than 7,500 with a history of cancer (representing 3.8 million working cancer survivors), and over 119,300 workers with no history of cancer (representing more than 100 million).

They found that among survivors, white collar workers on the whole had higher cancer screening rates than blue collar workers.

Clarke says this was a key finding that she hopes will lead to changes in employment policies to eliminate disparities among different groups of the working population of cancer survivors.

She hopes it will also spur researchers to look more closely at factors influencing screening rates so as to design better workplace interventions and encourage more workers in all occupations to take up screening.

She and her colleagues speculate that ongoing disputes over screening guidelines among bodies like the United States Preventive Services Task Force, American Cancer Society and others, plus reductions in rates of workers covered by insurance that have occurred in the past decade, may lie behind the trend.

Sunday 30 December 2012

Rice University Scientists Turn Soy Mash Into Succinic Acid

The humble soybean could become an inexpensive new source of a widely used chemical for plastics, textiles, drugs, solvents and as a food additive.

Succinic acid, traditionally drawn from petroleum, is one focus of research by Rice chemists George Bennett and Ka-Yiu San. In 2004, the Department of Energy named succinic acid one of 12 "platform" chemicals that could be produced from sugars by biological means and turned into high-value materials.

Several years ago, Rice patented a process by Bennett and San for the bio-based production of succinic acid that employed genetically modified E. coli bacteria to convert glucose into succinic acid in a way that would be competitive with petroleum-based production.

The new succinate process developed by Bennett, San and Chandresh Thakker and reported recently in Bioresource Technology promises to make even better use of a cheap and plentiful feedstock, primarily the indigestible parts of the soybean.

"We are trying to find a cheaper, renewable raw material to start with so the end product will be more profitable," said Thakker, a research scientist in the Bennett lab at Rice's BioScience Research Collaborative and lead author of the study. "The challenge has been to make this biomass process cost-competitive with the petrochemical methods people have been using for many years."

Bennett feels they have done that with soybean-derived feedstock as an inexpensive source of the carbon that microorganisms digest to produce the desired chemical via fermentation. "A lot of people use plant oils for cooking - corn or soybean or canola - instead of lard, as they did in the old days," he said. "The oils are among the main products of these seeds. Another product is protein, which is used as a high-quality food.

"What's left over is indigestible fiber and small carbohydrates," said Bennett, Rice's E. Dell Butcher Professor of Biochemistry and Cell Biology. "It's used in small amounts in certain animal feeds, but overall it's a very low-value material."

The Rice researchers are changing that with the help of E. coli bacteria engineered to process soy meal that generally gets discarded. Certain microbes naturally produce succinic acid from such feedstock, but manipulating E. coli's metabolic pathways (by eliminating pathways that produce other chemicals like ethanol, for instance) can make it far more efficient.

Expanding on their success in producing succinic acid from glucose, the new microbes are engineered to metabolize a variety of sugars found in soybean meal. The theoretical ideal is a 1:1 ratio of feedstock (the extracted sugars) to product, which they feel is achievable by industry. In the lab, under less controlled conditions, they still found the process highly efficient. "We're demonstrating a very high yield," Thakker said. "We're achieving in a flask a non-optimized formation of succinate that is close to the theoretical goal."

Bennett said his lab has been looking at soybeans for nearly three years. "We're always interested in low-cost feedstock," he said. "We were able to get a connection with a soybean group that is very interested in technologies to make better and more profitable use of their crop.

"There's a fair amount of oilseed residuals available, including cottonseed carbohydrates, that are not used for any high-value product, and we're in the space of microbial engineering to enable these sorts of materials to be used in a good way," he said.

Enzyme PRSS3 Linked To Aggressive Prostate Cancer

An enzyme, known as PRSS3, is specifically associated with aggressive prostate cancer risk, researchers from the Mayo Clinic, Florida reported this week in the journal Molecular Cancer Research.
The scientists, who claim they are the first to link the enzyme to prostate cancer, added that they have developed a compound that can stop PRSS3 from encouraging metastasis - when cancer spreads beyond its point of origin to other parts of the body.

Senior investigator, Evette Radisky, Ph.D., a cancer biologist, said:


"This molecule is a protease, which means it digests other molecules. Our data suggests PRSS3 activity changes the environment around prostate cancer cells - perhaps by freeing them from surrounding tissue - to promote malignancy and invasiveness.

I don't think PRSS3 is the only factor involved in driving aggressive prostate cancer, but it may be significant for a certain subset of this cancer - the kind that is potentially lethal."


Dr. Radisky and team had set out to determine, from data on previous clinical trials which had information on molecules that are irregularly switched on in cancer, which enzymes encouraged metastasis.

In a previous study they had identified a link between the protease and the initial stages of breast cancer.

They wanted to find out whether any other cancer abnormally expresses this protease, and when. They gathered and analyzed data from several sources.

A protease is an enzyme that breaks down proteins and peptides.

Dr. Radisky said:


"The link between PRSS3 activity and aggressive prostate cancer jumped out at us. We found a definitive trend of increasing PRSS3 expression with cancer progression."


In an animal experiment using mice with prostate cancer, they showed that protease expression was vital for prostate cancer metastasis. When PRSS3 was silenced, the cancer did not spread.

The team had previously crystallized the structure of the PRSS3 protease, and identified a place on the enzyme where a small protein therapeutic could bind to plug up the "scissoring" action of the molecule.

Dr Radisky said "The protease has an active site that breaks down other proteins, and our inhibiting agent sticks to the site, shutting it down."

The authors believe their breakthrough could pave the way for "several possible future clinical applications".

Prostate cancer patients could be tested for the presence of the enzyme, so that doctors could identify which ones had the highest risk of metastasis, Dr Radisky added.

The team have developed a "prototype drug", which they say provides a template upon which an agent could be used to treat patients with aggressive prostate cancer. Dr. Radisky said:


"Our inhibitor does not have the characteristics we need for a clinically useful drug. But it puts us on the right path to develop one."

Unhealthy Behavior Common Among University Students

An analysis of student lifestyles was carried out by researchers at the University of Vigo to evaluate how much students drink, whether or not they take illegal drugs, their diet and how much exercise they do. The results of the study published by the Journal of Environmental Research and Public Health indicates that a surprising number of students engage in unhealthy behavior, especially excessive drinking.
One of the main authors, Jose M. Cancela said: The amount drunk per unit of time is higher among women. In other words, even though male students drink more often, females do so more intensively in shorter periods of time, which is known as binge drinking."

A total of 985 students of various different courses at the University of Vigo were randomly selected to be interviewed. The results were slightly shocking and highlighted the extent of alcohol and substance abuse among students, especially women.

Of the men interviewed 41.7% admitted to living a sedentary lifestyle compared to 51.2% women. Women were also found to do a lot less exercise than men with only 20.9% of women doing physical exercise compared to 38.6% of men. Men took illegal drugs more often than women.

The researchers note:




"We were also surprised by the high consumption of illegal drugs among university students - 44.9% of men and 30.9% of women - which we understand could lead to significant future health problems, mainly related to the nervous system."


An irregular attitude to food was apparent in 8.8% percent of men and 16.6% of women. Students who took subjects like education were more likely to have an irregular attitude to food than students who took subjects such as health (19.2% vs 6.3%).

In 2008 universities across Spain set up a Healthy University Network which promoted healthy living for students across the country. The researchers believe that this was just a first step and that healthy habits should be encouraged as part of study plans.

Cancela concludes, "In the light of the results, training and information courses are required in these areas, together with healthy leisure - not just sports facilities - to set up university guidance services for a healthy student lifestyle


 The reason why some people are more vulnerable to alcohol than others was identified in a study published in PNAS. The gene called RASFR2 was found to regulate the predisposition to drink and influence the activity of mesolimbic dopamine neurons. This along with environmental factors, and other genes, is thought to be the reason why some people drink a lot more than others.

The affects of drinking alcohol as a student have been identified in a previous study published in Alcoholism: Clinical & Experimental Research. They found that students who binge drink have worse attention and visual working memory processes than those who don't and require much more effort to carry out certain tasks.

Case Files Anesthesiology (LANGE Case Files)

This summary is not available. Please click here to view the post.

Foundations of Anesthesia: Basic Sciences for Clinical Practice, 2nd Edition

This summary is not available. Please click here to view the post.

Stoelting’s Anesthesia and Co-Existing Disease: Expert Consult – Online and Print, 6th Edition (2012)

This summary is not available. Please click here to view the post.

Miller’s Anesthesia: Expert Consult Premium Edition – Enhanced Online Features and Print, 2-Volume Set, 7th Edition

This summary is not available. Please click here to view the post.

Cardiopulmonary Bypass: Principles and Practice (Gravlee) 3rd Edition

Established as the standard reference on cardiopulmonary bypass, Dr. Gravlee’s text is now in its Third Edition. This comprehensive, multidisciplinary text covers all aspects of cardiopulmonary bypass including sections on equipment, physiology and pathology, hematologic aspects, and clinical applications.
This edition features a new section on cardiopulmonary bypass in neonates, infants, and children and a new chapter on circulatory support for minimally invasive cardiac surgery. Other highlights include state-of-the-art information on low-volume circuits and other new equipment and discussions of outcomes data for on-pump and off-pump surgeries.
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GET IT HERE
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http://filepost.com/files/ed5a612b/0781768152.chm/

Manual of Perioperative Care in Adult Cardiac Surgery

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Saturday 29 December 2012

Acland’s Atlas of Human Anatomy (6 DVD)

The six DVDs in this remarkable and beautifully producedDVD anatomy
atlas explore the fundamental structures of the Musculoskeletal System,
the Head and Neck, and the Internal Organs. These DVDs show you true
images of real, exquisitely dissected human anatomical specimens, in
three dimensions. As the camera moves from one viewpoint to another, the
specimen appears to rotate in space, letting the viewer experience it
as a three-dimensional object. Acland’s DVD Atlas uses fresh,
un-embalmed specimens that retain the color, texture, mobility—and
beauty—of the living human body. A concise synchronized narration runs
throughout the program. As each new structure is shown, its name appears
on the screen. There is a self-testing feature at the end of each
section. Specific content can be accessed through detailed searches of
the index and table of contents. For students, Acland’s DVD Atlas is a
time-saving aid to first-time learning, an effective way to relearn
anatomy for clinical rotations, and a time-efficient tool for review.
For clinicians in training and in practice, it assures a swift renewal
of anatomic knowledge. For teachers, Acland’s DVD Atlas shortens the
time needed to provide immediate, satisfying explanations of
three-dimensional structure.
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GET IT HERE
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http://filepost.com/files/9m19919c/Acland%27s_Atlas_of_Human_Anatomy.part01.rar/
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Anatomy The Anatomical Basis of Clinical Practice (Gray’s Anatomy – 40th Edition)

This summary is not available. Please click here to view the post.

Friday 28 December 2012

Cardiac Surgery in the Adult, Third Edition

This summary is not available. Please click here to view the post.

Laboratory Tests and Diagnostic Procedures, 5th Edition

This summary is not available. Please click here to view the post.

What is Acne? What Causes Acne? How to Get Rid of Acne

The word acne comes from the word acme meaning "the highest point", which comes from the Greek akme meaning "point" or "spot" - it was originally mispelt, with an 'n' rather than an 'm' in 1835.

Acne is a disease that involves the oil glands of the skin. It is not dangerous, but can leave skin scars. Your skin has pores (tiny holes) which connect to oil glands located under the skin. The glands are connected to the pores via follicles - small canals. Sebum, an oily liquid, is produced by these glands. The sebum carries dead skin cells through the follicles to the surface of your skin. A small hair grows through the follicle out of the skin. Pimples grow when these follicles get blocked.

In humans, when pimples appear they tend to do so on the patient's face, back, chest, shoulders and neck. Acne develops when follicles get blocked and infected.

Simply put - skin cells, sebum and hair can clump together into a plug, this plug gets infected with bacteria, resulting in a swelling. A pimple starts to develop when the plug begins to break down.

There are various types of pimples


  • Whiteheads - remain under the skin and are very small.
  • Blackheads - clearly visible, they are black and appear on the surface of the skin. Remember that a blackhead is not caused by dirt. Scrubbing your face vigorously when you see blackheads will not help.
  • Papules - visible on the surface of the skin. They are small bumps, usually pink.
  • Pustules - clearly visible on the surface of the skin. They are red at their base and have pus at the top.
  • Nobules - clearly visible on the surface of the skin. They are large, solid pimples. They are painful and are embedded deep in the skin.
  • Cysts - clearly visible on the surface of the skin. They are painful, and are filled with pus. Cysts can easily cause scars.

How common is acne?

Dermatologists (skin specialists) say that approximately three-quarters of 11 to 30 year-olds will get acne at some time. Acne can affect people of all races and all ages. It most commonly affects adolescents and young adults. There are people in their fifties who still get acne. According to Brown University, USA, approximately 17 million Americans are estimated to have acne at any one time.

Although acne affects both men and women, young men suffer from acne for longer - probably because testosterone, which is present in higher quantities in young men, can make acne worse.

What causes acne?

Nobody is completely sure what causes acne. Experts believe the primary cause is a rise in androgen levels - androgen is a type of hormone. Androgen levels rise when a human becomes an adolescent. Rising androgen levels make the oil glands under your skin grow; the enlarged gland produces more oil. Excessive sebum can break down cellular walls in your pores, causing bacteria to grow.

Some studies indicate that susceptibility to acne could also be genetic. Some medications which contain androgen and lithium may cause acne. Greasy cosmetics may cause acne in some susceptible people. Hormone changes during pregnancy may cause acne to either develop for the first time, or to recur.

What causes acne - diagram

Treatment of acne

How your acne is treated may depend on how severe and persistent it is.

Treating mild acne

The majority of people who get acne will develop mild acne. This can usually be treated with OTC (over-the-counter) medications. OTC medications can be bought at a pharmacy without a doctor's prescription. They are usually applied to the skin - topical medicines.

Most acne OTC products may contain the following active ingredients:
  • Resorcinol - helps break down blackheads and whiteheads. It is a crystalline phenol and comes from various resins. Resorcinol is also used for treating dandruff, eczema and psoriasis.
  • Benzoyl Peroxide - kills bacteria and slows down your glands' production of oil. Benzoyl peroxide is a white crystalline peroxide used in bleaching (flour or oils or fats) and as a catalyst for free radical reactions. It works as a peeling agent, accelerating skin turnover and clearing pores, which in turn reduces the bacterial count in the affected area.
  • Salicylic Acid - helps break down blackheads and whiteheads, also reduces shedding of cells which line the follicles of the oil glands, effective in treating inflammation and swelling. Salicylic acid is a white crystalline substance which is also used as a fungicide, or in making aspirin or dyes or perfumes. It causes the epidermis to shed skin more easily, prevents pores from becoming blocked while at the same time allowing room for new cells to grow. It is commonly added to shampoos used for treating dandruff.
  • Sulfur - helps break down blackheads and whiteheads. Sulfur, in its native form, is a yellow crystalline solid. Sulfur has been used for centuries for treating acne, psoriasis and eczema. Scientists are not sure how sulfur works to help skin diseases. We do know that elemental sulfur does oxidize slowly to sulfurous acid which is a mild reducing and antibacterial agent.
  • Retin-A - helps unplug blocked pores. Retin-A contains Tretinoin, an acid from of vitamin A, also known as all-trans retinoic acid (ATRA). Tretinoin is also used for the treatment of acute promyelocytic leukemia. Retin-A has been used widely to combat aging of the skin, it also acts as a chemical peel.
  • Azelaic Acid - strengthens cells that line the follicles, stops oil eruptions, reduces bacteria growth. It is a saturated dicarboxylic acid found naturally in wheat, rye, and barley. Azelaic acid also mops up free radicals, which reduces inflammation. It is useful for patients with darker skin who have dark patches on their face (melasma), or whose acne spots leave persistent brown marks.
You can buy acne medications in the forms of gels, soaps, pads, creams and lotions. If your skin is sensitive you may prefer a cream or lotion. Gels, which are usually alcohol based and tend to dry the skin, are better for people with oily skin. OTC medications will have these ingredients in different concentrations. It is advisable to start with the lowest strengths. You may experience skin irritation, redness, and/or burning when you first try them. These side effects usually go away after continued use. If they don't you should see your doctor.

Virus may be possible acne cure - researchers from the University of Pittsburgh believe that a virus that lives on our skin might one day be used to effectively treat acne.

Treating more severe cases of acne

If your acne is more severe you should consider seeing a dermatologist - a skin specialist. The specialist may prescribe a treatment that contains some of the active ingredients mentioned above, such as benzoyl peroxide, azelaic acid, as well as adabalene. Prescription medications for acne are presented in many forms, such as creams, lotions, etc. Your dermatologist will decide what is best for you.

You may be prescribed an oral or topical antibiotic. Antibiotics can combat the growth of bacteria and reduce inflammation. Most commonly Erythromyocin and Tetracycline are prescribed as antibiotics for the treatment of acne.
  • Treating a cyst with interlesional corticosteroid injection
    If an acne cyst becomes severely inflamed there is a high risk of rupturing. A rupturing acne cyst can often result in scarring. The specialist may inject a diluted corticosteroid to treat the inflamed cyst and to prevent scarring. The injection will lower the inflammation and speed up healing. The cyst will "melt" within a few days.
  • Isotretinoin
    This is a strong oral retinoid, used for the treatment of severe cystic acne, as well as severe acne that has not responded to other medications and treatments.
  • Oral antibiotics
    Oral antibiotics are frequently prescribed for patients with severe acne and some patients with moderate acne too. The aim of such oral antibiotics is to lower the population of Propionibacterium acnes (P. acnes), a bacterium commonly found on the skin, which will multiply rapidly in blocked follicles. The dosage will be initially high, and then as the acne reduces so will the dosage. Antibiotics are not taken for more than six months. As time passes the P. acnes can become resistant to the antibiotic and another antibiotic is needed. Some American studies have indicated that it is better to use oral broad-spectrum antibiotics.
  • Oral contraceptives
    The majority of women with acne find that taking certain oral contraceptives clears it up. Oral contraceptives suppress the overactive gland and are commonly used as long-term treatments for acne in women. If the woman has a blood-clotting disorder, smokes, has a history of migraines, or is over 35, she should not take this medication without checking with a gynecologist first.
  • Topical antimicrobials (topical = applied to the skin or mucus membranes)
    As with oral antibiotics, the aim of topical antimicrobials for the treatment of acne is to reduce P. acnes populations. Topical antimicrobials are used for patients with moderate to severe acne. Examples may be clindamycin, erythromycin, and sodium sulfacetamide
    The dermatologist may prescribe a topical retinoid. Topical retinoids are a derivative of Vitamin A and are very popular for the treatment of acne. They unclog the pores and prevent whiteheads and blackheads from developing. Examples of topical retinoids prescribed in the USA are adapalene, tazarotene, and tretinoin.


Looking after your skin if you have acne (or are prone to acne)


  • Wash your face about twice each day. Do not wash it more often. Use a mild soap made especially for people with acne, and warm water. Do not scrub the skin. Experts advise the use of an OTC lotion which contains benzoyl peroxide.
  • Don't try to burst the pimples. You may push the infection further down, causing more blocking and worse swelling and redness. Popping pimples makes scarring more likely.
  • If you have to get rid of a pimple for some event, such as a wedding, or public speaking occasions, ask a specialist to treat it for you.
  • Try to refrain from touching your face with your hands. When you are on the phone try not to let the receiver touch your face - there may be sebum and skin residue on it.
  • Keep your hands clean, wash them regularly.
  • Always wash your hands before touching your face. This includes before applying lotions, creams or makeup.
  • Glasses should be cleaned regularly. They will collect sebum and skin residue.
  • You skin needs to breathe. If your acne is on your back, shoulders or chest try wearing loose clothing. Tight garments, such as headbands, caps and scarves should be avoided - if you have to wear them make sure they are cleaned regularly.
  • Don't go to sleep with makeup on. Only use makeup that is nonceomedogenic or nonacnegenic - you should be able to read this on the label. If you cannot find it, ask the shopkeeper or pharmacist. You should use makeup which does not have oil and does not clog up the pores.
  • Hair collects sebum and skin residue. Keep your hair clean and away from your face.
  • Too much sun can cause your skin to produce more sebum. Several acne medications make it more likely that you will be sunburned.
  • If you shave your face, do it carefully. Use either an electric shaver or safety razors. If you use a safety razor make sure the blade is sharp. Soften your skin/beard with warm soapy water before applying the shaving cream.

Other articles about skin conditions/diseases

What is psoriasis? What causes psoriasis?

What are skin tags? What causes skin tags?

What are pimples? How to get rid of pimples

What are blackheads? How to get rid of blackheads

What Are Hives? What Is Urticaria? What Causes Hives?

What are warts? What causes warts?

What are genital warts? What causes genital warts?

What is dandruff? What causes dandruff?

What is nail fungal infection? What causes nail fungal infection?

What is skin cancer? What is melanoma?

What can make acne worse?


  • Menstrual cycle - Girls and women with acne tend to get it worse one or two weeks before their menstrual period arrives. This is probably due to hormonal changes that take place. Some people say they eat more chocolate during this time and wonder whether there may be a connection. However, experts believe the worsening acne is not due to chocolate, but rather to hormonal changes.
  • Anxiety and stress - mental stress can affect your levels of some hormones, such as cortisol and adrenaline, which in turn can make acne worse. Again, stress can make some people binge-eat. Experts believe the culprits are most likely the hormone levels, rather than the binge-eating.
  • Hot and humid climates - when it is hot and humid we sweat more. This can make the acne worse.
  • Oil based makeups - moisturizing creams, lubricating lotions, and all makeup that contain oil can speed up the blocking of your pores.
  • Greasy hair - some hair products are very greasy and might have the same effect as oil based makeup. Hair products with cocoa butter or coconut butter are examples.
  • Squeezing the pimples - if you try to squeeze pimples your acne is more likely to get worse, plus you risk scarring.